Congrats Rob for the Presidential Graduate Fellowship!!
Nir Yakoby September 18, 2015

Congratulations to Rob Marmion for receiving the Presidential Graduate Fellowship for doctoral study in Comput… Read More

Congratulations Alessio! you did it!
Nir Yakoby May 22, 2015

Congratulations Alessio for graduation with a BS degree in Biology and Chemistry. Good luck in the MS program!… Read More

Congratulations Alessio! Weissman Prize!
Nir Yakoby May 19, 2015

Congratulations Alessio¬†Russomanno for receiving the Gerald S. Weissman Memorial Prize in Biology for excellen… Read More

Tissue Patterning and Morphogenesis

egg patterningThe main interest of our laboratory is to understand mechanisms underlying cell fate determination by cell signaling. We focus on the two highly conserved signaling pathways, the bone morphogenetic protein (BMP) and epidermal growth factor receptor (EGFR), and use fruit fly egg formation, oogenesis, as a model system.

The egg chamber (left) is the precursor of the mature egg (right). The oocyte is surrounded by a mono-layer of follicle cells (FCs), which forms the 3D intricate structures of the Drosophila eggshell. Eggshell structures, such as the dorsal appendages (DAs), are formed by two non-overlapping populations of cells. Cells expressing Rhomboid (Rho) form the future floor of the DAs, and cells expressing Broad (BR) form the future roof of the DAs. Other structures include the operculum (Op – an opening for larvae hatching), and a micropyle (M – the point of sperm entry).

Eggshell copyEggshell structures are highly diverse among fly species. Morphological diversity includes the numbers and shapes of the DAs, and the lumen-like dorsal ridge and respiratory stripe.

We are interested to understand the evolution of BMP signaling dynamics across Drosophila species, that is regulated by the pattern of the type I BMP receptor spatial expression. In addition, we aim to understand how spatiotemporal changes in EGFR activation are regulated by different distributions of Gurken, a TGF-alpha-like ligand..


National Institute of Health  National Science Foundation